Models animals per a l'estudi de la diabetis Authors Núria Roglans Marta Alegret Juan Carlos Laguna Abstract Animal experimental models for the study of diabetes. Diabetes mellitus (DM) originates from a lack of insulin effects, due to a deficit of pancreatic production, or to an inadequate response of target organs, or a combination of both situations, ensuing hyperglycaemia, polyuria and polydipsia. When insulin is totally absent (Type 1 DM), there is an increased metabolism of muscular protein and fat, ending in metabolic ketoacidosis and death. With a residual insulin activity (Type 2 DM), diabetes becomes chronic, with obesity, micro- and macroangiopathies and their corresponding clinical manifestations (renal failure, retinal alterations, neuropathies, myocardial infarct, etc.). DM is a serious health problem and, as it is a complex illness, in which participate genetic and acquired factors, there is not a single perfect animal model for its study, able to reproduce all the characteristics of the human malady. The great majority of models use rodents, given their advantages: small size, easy access, fast reproduction rate, and a feasible genetic manipulation. We will discuss about induced models, in which the illness is reproduced by means of a specific manipulation, spontaneous models, comprised by animal breeds genetically selected along successive generations in order to them to develop the malady, and genetically engineered models. Downloads Download data is not yet available. Downloads Text complet (Català) Published 2012-01-19 Issue 62, 2011 : Organismes model en biologia / Montserrat Corominas i Marc Valls editors Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
