El bacteriòfag lambda, un model de decisió genètica Authors Maite Muniesa Abstract The bacteriophage lambda. The bacteriophage lambda (phage λ) is a virus that infects the intestinal bacteria Escherichia coli. Phage λ has been historically used as a model microorganism on the study of virus multiplication, and moreover for the genetic regulation of its multiplicative cycles. Phage λ has two different multiplicative pathways, called lytic and lysogenic cycles, and can choose among both cycles by a complex system of genetic regulation. If the lytic cycle is selected, λ multiplies within the bacteria generating new phages. The new phages release outside the bacteria by lysis, which causes the death of the cell. If the lysogenic cycle is selected, the phage DNA is integrated within the bacterial DNA and remains in a latent state (prophage) as a part of the bacterial genome. This cycle does not kill the bacterial cell, that can continue its replication together with the replication of the phage DNA. This allows the bacterium to express its own genes and those of the phage. Lysogeny can remain stable or revert towards the lytic cycle, if there are certain environmental factors that affect viability of the bacteria. Phage λ has also been applied as a tool for diverse molecular biology applications. Among others, the production of recombinant DNA, using the abilities of their enzymes to integrate DNA fragments within the bacterial genome. Downloads Download data is not yet available. Downloads Text complet (Català) Published 2012-01-17 Issue 62, 2011 : Organismes model en biologia / Montserrat Corominas i Marc Valls editors Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
