La Tuberculosi? no s'havia eradicat? cent anys del bacteri més persistent Authors Pere-Joan Cardona Abstract This work pretends to offer a view on the fight against tuberculosis in Catalonia 100 years ago, summarizing aspects on its epidemiology, prophylaxis and treatment. It also explains the contribution of catalonian researchers in the study of its etiopathogenesis: The mutability theory of Dr. Ferran and the design of the anti-alpha vaccine. The refinement of this theory that led to the theory Ravetllat-Pla and the introduction of a new therapy based on the administration of specific serum against the attack form of the bacilli. And the studies of Dr. Conrad Xalabarder on the cell wall deficient forms. Furthermore, it is highlighted the challenges that still remain. The lack of knowledge on the mechanisms that led to latent tuberculosis infection or the induction of the most characteristic lesion: the pulmonary cavity. In this regard the contributions of our group in these fields are summarized. Mainly based in the dynamic hypothesis, that considers the infection as a continuous process of endogenous reinfection. This theory supports that the design of vaccines able to avoid it are impossible, and has been the bases for the design of the therapeutic vaccine RUTI, which will allow the reduction of, chemotherapy treatment. Downloads Text complet (Català) Published 2014-02-26 Issue 64, 2013 : Les malalties del segle XXI / Jordi Barquinero i Jaume Reventós, editors Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
