Animals transgènics en recerca i models animals de malalties Authors Lluís Montoliu Abstract Animal experimentation is essential to allow the adequate interpretation of the human genome and to reproduce the pathologies that affect us, as human beings, in other similar organisms. Among them, mice stand up as a small size mammal that is very suitable for research in biomedicine. The mouse genome has also been sequenced and, mostly, shares with the human genome the number of existing gens, situated between 20.000 and 25.000 genes. Additionally, all these genes have been highly conserved through evolution, thus being 95% similar to the corresponding human versions. For all this, research on genes from the mouse genome, indirectly, is also research on the function of human genes. Everything that we can learn by investigating the function of specific genes in the mouse can be applied to our knowledge on the corresponding homologous genes in humans. Finally, mice also allow the manipulation of their genome through genetic modification techniques. These are known as transgenic or mutant mice, carrying new genes or specif - ic alterations in some of their genes. With them, it is possible to generate animal models of many diseases affecting humans, to increase our knowledge on them and to eventually be able to develop new therapeutic strategies. Downloads Download data is not yet available. Downloads Text complet (Català) Published 2011-01-19 Issue 61, 2010 : Organismes modificats genèticament / Josep M. Casacuberta, editor Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
