Derivació de línies de cèl·lules mare embrionàries humanes

Authors

  • Begoña Aran Corbella
  • Ignasi Rodríguez-Pizà
  • Ángel Raya
  • Yolanda Muñoz Santos
  • Pere Nolasc Barri Ragué
  • Juan Carlos Izpisúa Belmonte
  • Anna Veiga i Lluch

Abstract

Human embryonic stem cells (hESC) represent a potential source for cell therapy for many degenerative diseases. Usually hESC lines are derived from surplus embryos donated from couples undergoing In Vitro Fertilisation (IVF). We here present the results obtained in the Stem Cell Bank at the Center of Regenerative Medicine in Barcelona. 254 embryos have been thawed. The embryos were donated from couples from the IVF programme at the Institut Universitari Dexeus. The embryo survival rate was 51.9%. Five ESC lines were obtained. Three of these lines came from poor quality embryos. The cell lines present self-renewal, pluripotency, and differentiation properties characteristic of these cells Poor quality embryos, usually discarded in assisted reproduction centres, could be useful for ESC derivation.

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Published

2009-04-29