Diagnòstic genètic preimplantacional en estadis embrionaris tardans Authors Mònica Parriego Anna Veiga i Lluch Francesca Vidal Abstract The incorporation of blastocyst biopsy into clinical practice can be considered as a valid alternative when performing PGD. The fact that it makes more material available for analysis is of particular value in those cases where the aim is to diagnose monogenic diseases. The availability of a greater number of cells opens the possibility of performing multiple diagdiagnoses in parallel on the same embryo; these could be used to detect multigenic diseases or for the combined diagnosis of different disorders through diagnostic approaches based on both FISH and PCR. Embryos transferred at the blastocyst stage are subjected to a dual selection process (genetic and through culture) and this is reflected in their greater implantation potential, thus enabling a lower number of embryos to be transferred, which in turn reduces the risk of multiple pregnancy. Although the clinical application of blastocyst biopsy for PGD remains a limited and recent development, the good results in terms of implantation and pregnancy rates obtained so far, as well as the diagnostic possibilities it opens up, suggest that this technique can become more widely used in the early future. Downloads Download data is not yet available. Downloads Text complet (Català) Published 2009-04-27 Issue 59, 2008 : Biologia de la reproducció / Mercè Durfort i Francesca Vidal, editores Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
