Fragmentació del DNA espermàtic

Authors

  • Margarida Esbert Algam
  • Alberto Pacheco
  • Mireia Florensa Bargalló
  • Marissa Riqueros
  • Marta Martín Salat
  • Agustín Ballesteros Boluda
  • Gloria Calderón

Abstract

DNA fragmentation is the last phenomenon occurred during apoptosis. It is known that Fas-mediated apoptosis is the way used in testes to control the number of germ cells that are excessive with the supportive capacity of the Sertoli cells. Even dough, spermatozoa that have been earmarked to undergo apoptosis escape this process. Other potential source of sperm DNA damage is oxidative stress due to reactive oxygen species (produced by leukocytes present in ejaculate, but also by other spermatozoa) and deficiencies in natural processes such as recombination and chromatin packaging that involves the induction of DNA strand breaks. It seems clear that DNA damage on sperm is related to male fertility but it is still controversial if this DNA fragmentation has an effect when Assisted Reproduction Techniques are performed, due to natural steps are bypassed and there is also an oocyte effect that can not be forgotten.

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Published

2009-04-27