Desxifrant la base molecular de la formació de l'ou en els peixos marins

Authors

  • Joan Cerdà Luque

Abstract

The hydration of the oocyte of marine fish during the last stages of egg formation is a critical factor for the correct development and survival of the embryo. However, although increasing information is available on the mechanisms that control meiotic maduration in fish oocytes, the identification of the molecular mechanisms involved in oocyte hydration remain elusive. In this work, I review the studies that have identified the main osmotic effectors playing a role during oocyte hydration, as well as recent works that have discovered for first time the function of a novel molecular water channel (aquaporin, AQP) during this process. This channel, called aquaporin-1b (Aqp1b), belongs to a new subfamily of AQPs, similar to the mammalian aquaporin-1 (AQP1), that has evolved specifically in teleosts possibly by gene duplication, followed by structural divergence at the C terminus of the protein and acquisition of regulatory domains for the control of intracellular transport, and further neofunctionalization in oocytes for water uptake. These studies are thus contributing to uncover the molecular basis of the production of viable eggs in marine fish.

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Published

2009-04-27