Nous fàrmacs : medicina personalitzada Authors José Maria Palacios Sonsoles Musoles Abstract The development of methodologies allowing for the sequencing of individual genomes in a rapid manner and with acceptable costs allows us to think that in the future it will be possible to speak of personalized medicine, i.e., the possibility to treat a particular patient with the drug for the right indication at the right dose. This should help to avoid the lack of efficacy and safety of a good part of the drugs used currently that is linked to the great genetic variability in the general population with regard to the sites of actions of drugs as well as in the mechanisms determining their absorption, metabolism and excretion. Pharmacogenetics and more widely pharmacogenomics are the sciences in which personalized medicine is based. The most important change in the development of new medicines in the postgenomic era is linked to the necessity of developing, at the same time, both a diagnostic assay and a targeted treatment. The fulfilment of the promises of pharmacogenomics has implications far beyond the pure scientific aspects as it requires a radical change in the way medicine is currently practised with ethical, legal, regulatory and economic implications. This paper reviews the differences between the traditional drug development and the changes introduced by the use of genetic information in the development of new therapies. Downloads Text complet (Català) Published 2009-02-16 Issue 58, 2007 : Les biotecnologies / Pere Puigdomènech i Francesc Gòdia, editors Section Les aplicacions: salut, alimentació, indústria i medi ambient License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
