Factors angiogènics en la retinopatia diabètica proliferativa Authors Marta Garcia-Ramírez Cristina Hernández Esther Carrasco Rafael Simó Canonge Abstract Diabetic retinopathy is the leading cause of legal blindness among working-aged individuals. Neuroretinal damage, thickening of the capillary basement membrane and a loss of pericytes and endothelial cells are among the earliest histological features. Neovascularization, the hallmark of proliferative diabetic retinopathy (PDR), occurs in the advanced stages and is the main cause of blindness in type 1 diabetes. Macular edema is another retinal complication of diabetes that is responsible for a major part of vision loss, particularly in type 2 diabetes. Vascular leakage, as a consequence of a breakdown in the blood retinal barrier, is the main event involved in its pathogenesis. Apart from controlling blood glucose and blood pressure, laser photocoagulation treatment is the only tool in the current armamentarium against diabetic retinopathy progression. Therefore, new pharmacological treatments, based on an understanding of the patho-physiological mechanisms of diabetic retinopathy, have been developed in recent years. There is mounting evidence to suggest that angiogenic factors play a crucial role in PDR development, with vascular endothelial growth factor (VEGF) being the most relevant. Other growth factors or cytokines, such as insulin-like growth factor I (IGF-1), hepatocyte growth factor (HGF), basic fibroblast growth factor (b-FGF), platelet derived growth factor (PDGF), pro-inflammatory cytokines and angiopoietins, are also involved in the pathogenesis of PDR. Downloads Text complet (Català) Published 2007-12-28 Issue 56, 2005 : Endocrinologia molecular / Jaume Reventós editor Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
