Sex hormone-binding globulin (SHBG) in the ovary Authors Thierry Forges Anne Gérard Patricia Monnier-Barbarino Hubert Gérard Abstract Sex hormone-binding globulin (SHBG) was described in the late sixties as a hepatic carrier protein for sex steroids and was thought to regulate their bio-availability. It has also been known for many years that testicular Sertoli cells express androgen-binding protein (ABP), which is encoded by the same gene as SHBG, but which is differentially glycosylated. The possible roles of ABP have been extensively studied, and this protein may be one of the local regulators of spermatogenesis. In contrast, very few authors have investigated the presence of SHBG in the ovary. The aim of the present paper is to provide a survey of what is currently known about the expression of SHBG in the female gonad, including our own recent findings that SHBG was present in ovarian follicles. This was true, particularly in the cytoplasm of granulosa cells, some theca cells, and oocytes in primordial, primary, and early secondary follicles, as well as in the corpus luteum. Furthermore, the expression of the SHBG gene has been demonstrated in granulosa-lutein cells from in vitro fertilization patients, indicating that these cells are one of the local sources of SHBG in the human ovary. These new data suggest an involvement of SHBG in ovarian physiology. Downloads Text complet (Català) Published 2007-12-28 Issue 56, 2005 : Endocrinologia molecular / Jaume Reventós editor Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
