Noves tecnologies en la recerca d'antimicrobians Authors Antonio Giuglietta José Terencio Celia Palacín Cristina Alemany Boor Cristina Tarragó Abstract Infectious diseases are the leading cause of death worldwide, and the main reasons for the accelerated development and dissemination of bacterial resistance are the increase of the global selective pressure through inappropriate use of antimicrobials in therapy, the bacterial ability to select for resistant organisms, and the lack of development of new drugs as fast as bacteria can adapt to current antibacterials. The scientific community and drug companies are refocusing their discovery efforts in developing novel agents with new modes of action, adding to the classical antibiotic knowledge and detection methods the use of rapidly emerging technologies including genomics, combinatorial chemistry, high throughput scanning, and novel sources of natural products. This review summarize the evolution of the antimicrobial drug discovery process through the use of novel technologies in order to fight against resistant pathogens. Downloads Text complet (Català) Published 2006-02-01 Issue 55 : Antimicrobians / Joaquim Ruiz editor Section Antimicrobians: generalitats License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
