Mecanismes d'acció dels antifúngics i resistència en llevats Authors Josep M. Torres Rodríguez Yolanda Morera Eidi Alvarado Ramírez Abstract Most of our knowledge on antifungal resistance mechanisms is related to yeasts and azoles. Fluconazole is the most studied antifungal and several resistance mechanisms have been demonstrated. Efflux pump seems to be the most important, but cell-target changes and modifi- cations in the ergosterol metabolic way are also relevant. CDR1 and BEN-R are two genes involved in those resistance mechanisms. Resistance is not a major clinical problem with amphotericin B and echinocandins, but Candida albicans can have secondary resistances to 5-fluorocitosyne when enzymatic activity is lost and the active metabolite is lacking. Relationship among antifungal resistance and therapeutic response has been shown in experimental animal models and in clinical studies, but response to the treatment is also related to immunological status of the patient as well to the fungal species, and pharmacological aspects of the drug. Downloads Text complet (Català) Published 2006-02-01 Issue 55 : Antimicrobians / Joaquim Ruiz editor Section Altres antimicrobians License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
