Monkeypox (mpox)

Authors

Keywords:

poxvirus, monkeypox, outbreak, emergency, review.

Abstract

Poxviruses are among the most successful zoonotic viruses in terms of host range and evolution. Within the genus Orthopoxvirus, we find the most devastating viral pathogen in human history (smallpox) and a number of humanand animal-infecting species. One of them, monkeypox virus (later named mpox), is a zoonotic virus endemic to some central and western African countries. While the COVID-19 pandemic was still ongoing but at much lower rate, a completely different species (mpox, a large double stranded DNA virus) stole the limelight of human viral threats. Indeed, human mpox infections had previously been rare or limited to specific outbreaks, but the global mpox epidemic in 2022 exceeded all predictions and was declared a public health emergency of international concern by the World Health Organization in July of that year. To date, more than 90,000 cases in more than 100 countries have been reported. In this review, we summarize the updated knowledge on the main virological, epidemiological, clinical, diagnostic, and treatment- and prevention-related aspects of this intriguing emerging virus.

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Published

2024-12-09

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Articles