Variability and massive sequencing of viruses. SARS-CoV-2 as an example Authors Cristina Andrés Vall d’Hebron Institut de Recerca (VHIR) David Tabernero Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Tomás Pumarola Vall d’Hebron Institut de Recerca (VHIR) Andrés Antón Vall d’Hebron Institut de Recerca (VHIR) Josep Quer Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Keywords: variability, virus, massive sequencing, NGS, diagnosis. Abstract One of the things that we have learned in the last two years, specifically from the SARS-CoV-2 pandemic, is that we cannot wall in viruses to prevent their propagation, and that the most effective way to combat them is to ensure their rapid detection and genetic characterisation. Pandemics caused by viruses have broken out in the past, we are currently experiencing such a pandemic, and sooner or later we will surely be struck by another one. The risk of new pandemics has grown in recent years, due to factors favouring their appearance such as the destruction of natural areas, the ease of long-distance travel in a matter of hours, climate change, and the increase of human concentrations and social activities in a constantly more globalised world. In this respect, massive or next-generation sequencing (NGS) has proven to be a very powerful tool that has been of help in diagnosis and in the development of vaccines, the identification and monitoring of variants, and the study of the biology of the virus. The SARS-CoV-2 pandemic has allowed to demonstrate the utility of NGS as well as the need to strengthen the network of sequencing laboratories. The better we are prepared, the quicker and more effective will be our response to a possible threat. Downloads Download data is not yet available. Downloads PDF (Català) Issue Vol. 72 (2022) Section Articles License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
