Next-generation sequencing technologies open a new era in genomics

Authors

  • Mònica Bayés Centre Nacional d’Anàlisi Genòmica (CNAG-CRG)

Keywords:

genomics, massive sequencing, genome, exome, personalized medicine.

Abstract

DNA sequencing technologies and applications have undergone a remarkable evolution during the last few years. Next-generation sequencing (NGS) technologies enable the collection of genome-wide information from a sample and the identification of the DNA nucleotide sequence, the levels of gene expression and/or the nucleotide modification profiles, very rapidly and at relatively low costs. They produce an overwhelming amount of data that is interpreted within a bioinformatics framework that requires significant computational infrastructure. NGS advances open up new opportunities in genomics-assisted breeding of crops and livestock, in research about the molecular base of human diseases and clinical molecular diagnostics, and in the development of new therapies and the discovery of new infectious agents.

Keywords: genomics, massive sequencing, genome, exome, personalized medicine.

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Issue

Vol. 66 (2015)

Section

Destacats de recerca

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