Fatty acid oxidation regulation strategies to treat obesity

Authors

  • Laura Herrero 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB) 3. CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn)
  • Joan Francesc Mir 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB)
  • Minéia Weber 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB)
  • Raquel Fucho 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB)
  • María Calderón 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB) 3. CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn)
  • Dolors Serra 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB) 3. CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn)

Keywords:

Obesitat, ingesta, oxidació d’àcids grassos, CPT1.

Abstract

Current lifestyles, with high-energy diets and little exercise, are triggering an alarming growth in obesity. Strategies that enhance fat degradation or reduce caloric food intake could be considered therapeutic interventions to reduce not only obesity, but also its associated disorders. The enzyme carnitine palmitoyltransferase I (CPT1) is the critical rate-determining
regulator of fatty acid oxidation. In this paper, we show that this enzyme might play a key role in different tissues, such as liver, adipose tissue and hypothalamus, increasing energy expenditure and controlling food intake.

Keywords: Obesity, food intake, fatty acid oxidation, CPT1.

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Author Biography

Laura Herrero, 1. Universitat de Barcelona. Facultat de Farmàcia. Departament de Bioquímica i Biologia Molecular 2. Institut de Biomedicina de la Universitat de Barcelona (IBUB) 3. CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn)

 

 

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Issue

No. 14 (2015)

Section

Articles

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