Promises and hazards of gene therapy: giants or windmills? Authors Jordi Barquinero Vall d’Hebron Institut de Recerca Keywords: gene therapy, bioethics, germ gene therapy, genome editing. Abstract After 25 years of ups and downs, gene therapy has reached adulthood as a scientific discipline and we no longer say that it is an attractive future possibility but rather a reality that is healing and improving the quality of life of an increasing number of patients. This winding road, however, has been accompanied by a parallel bioethical debate that is closely related to the peculiarities and the very essence of this discipline. Many of the initial fears about what was then known have already faded, but others have emerged such as the realization of the dangers and risks of the use of oncogenic integrative vectors, the high costs of the first products that have reached the market or the cosmetic use of gene therapy tools. More recently, in light of the discovery of new and efficient tools for gene or genome editing, the old debate about the possibilities of germ-line gene therapy has reemerged, a subject that has been taboo and indeed explicitly prohibited in most countries that have legislated on this subject.Keywords: gene therapy, bioethics, germ gene therapy, genome editing. Downloads Download data is not yet available. Downloads PDF (Català) Issue Vol. 67 (2016) Section Destacats de recerca License The intellectual property of the articles belongs to the respective authors. At the time of submitting the articles to Treballs de la Societat Catalana de Biologia, authors accept the following terms: — Authors assign to the SCB (a subsidiary of the Institut d’Estudis Catalans) the rights of reproduction, public communication (including communication through social networks) and distribution of the articles submitted for publication to Treballs de la Societat Catalana de Biologia, in any form and medium, including digital platforms. The Publications Committee reserves the right to accept or refuse submitted articles and the right to make any editorial changes it deems appropriate. If the suggested changes are accepted by authors, they should re-submit the article with such changes. — Authors answer to the SCB for the authorship and originality of submitted articles. In other words, authors assure that submitted articles do not contain fragments of works by other authors or fragments of their own previously published works; that the content of articles is original, and that the copyright of third parties is not infringed upon. Authors accept this responsibility and undertake to hold harmless the SCB for any loss or damage resulting from non-compliance with this obligation. Furthermore, they should include a statement in articles submitted to the journal regarding their responsibility for the content of the articles. — Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles, and they should moreover ensure that images, videos, etc., have been created with the consent of the individuals appearing in them, and that material belonging to third parties is clearly identified and acknowledged as such within the text. Likewise, authors should provide the respective consents and authorisations to the SCB when submitting articles. — The SCB is exempt from any liability arising from the possible infringement of intellectual property rights by authors. In all cases, it undertakes to publish corrections, clarifications, retractions and apologies, if necessary. — Unless otherwise stated in the text or in the graphic material, the contents published in the journal are subject to an Attribution - NonCommercial - NoDerivs 3.0 Spain (by-nc-nd) license from Creative Commons, the full text of which may be consulted at https://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Therefore, the general public is authorised to reproduce, distribute and communicate articles as long as their authorship and publishing entity are acknowledged, and no commercial use is made of them nor derivative work produced from them. — The journal is not responsible for the ideas and opinions expressed by the authors of published articles.
