Inflammation negative control mechanisms mediated by nuclear receptors

Authors

  • Jonathan Matalonga Grup de Receptors Nuclears, Departament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona
  • Annabel F. Valledor Departament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona.

Keywords:

nuclear receptor, inflammation, transrepression, gene expression.

Abstract

Nuclear receptors are a superfamily of ligand-dependent transcription factors that regulate reproduction, development, metabolism and immune responses. Several nuclear receptors play an important role in the negative control of inflammation. In this review we will focus on those nuclear receptors with better characterised anti-inflammatory roles and the molecular mechanisms underlying their actions.

Key words: nuclear receptor, inflammation, transrepression, gene expression.

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