Chemical biology: Chemistry as an essential tool in biology Authors Gemma Triola Institut de Química Avançada de Catalunya (IQAC, CSIC). Departament de Química Biomèdica Keywords: Chemical biology, bioorthogonal reactions, protein synthesis and modification, Ras proteins. Abstract Chemical biology relies on the use of chemical tools for the characterization of biological processes. In the last decade, this multidisciplinary research area involving organic chemistry as well as molecular, cellular and structural biology and biophysics, among other fields, has played a key role in the identification of protein function and its importance in complex cellular signalling networks and especially in the elucidation of the molecular principles regulating biological processes in both health and disease. This paper presents some examples and describes some of the major research areas in chemical biology, including the design and synthesis of molecules to modulate protein activity and interactions, the synthesis of fluorescent reporters and the development of chemical methods enabling protein synthesis, modification and immobilization.Keywords: Chemical biology, bioorthogonal reactions, protein synthesis and modification, Ras proteins. Downloads Download data is not yet available. Downloads PDF (Català) Issue No. 12 (2013) Section Articles License The intellectual property of articles belongs to the respective authors. On submitting articles for publication to the journal Revista de la Societat Catalana de Química, authors accept the following terms:Authors assign to Catalan Society of Chemistry (a subsidiary of Institut d’Estudis Catalans) the rights of reproduction, communication to the public and distribution of the articles submitted for publication to Revista de la Societat Catalana de Química.Authors answer to Catalan Society of Chemistry for the authorship and originality of submitted articles.Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles.Catalan Society of Chemistry declines all liability for the possible infringement of intellectual property rights by authors.The contents published in the journal, unless otherwise stated in the text or in the graphic material, are subject to a Creative Commons Attribution-NonCommercial-NoDerivs (by-nc-nd) 3.0 Spain licence, the complete text of which may be found at http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Consequently, the general public is authorised to reproduce, distribute and communicate the work, provided that its authorship and the body publishing it are acknowledged, and that no commercial use and no derivative works are made of it.The journal is not responsible for the ideas and opinions expressed by the authors of the published articles.
