Design and synthesis of cysteine protease inhibitors

Authors

  • Florenci V. González Universitat Jaume I (UJI). Departament de Química Inorgànica i Orgànica

DOI:

https://doi.org/10.2436/20.2003.01.144

Keywords:

Cysteine proteases, inhibitors, peptidomimetics

Abstract

Small molecules acting as cysteine protease inhibitors have been designed according to the enzyme’s mechanism of action. These inhibitors have been synthesized and tested against parasitic cysteine proteases related to infectious diseases. The inhibitors display a general structure with two parts: a peptidomimetic part recognized by the active center and an electrophilic group (“warhead”) which is reactive with cysteine. The reactivity of the warhead with the cysteine thiol determines the inhibition kinetics.

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Author Biography

Florenci V. González, Universitat Jaume I (UJI). Departament de Química Inorgànica i Orgànica

Florenci V. González és doctor en química per la Universitat Jaume I (UJI) des del 1995. Els anys 1997-1998 va fer una estada postdoctoral a la Universitat d’Indiana amb el professor William R. Roush, i el 1999, a la Universitat Estatal de Colorado amb el professor Robert M. Williams. El 2001 va ser professor titular de l’UJI i des d’enguany és catedràtic de química orgànica d’aquesta mateixa universitat. Els seus camps d’investigació són el descobriment de fàrmacs i el desenvolupament de noves reaccions químiques. Ha publicat més de seixanta articles d’investigació i ha estat professor visitant a la Universitat de Bath i a la Northwestern University.

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Published

2023-12-15

Issue

No. 22 (2023)

Section

Articles

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