Design and synthesis of cysteine protease inhibitors Authors Florenci V. González Universitat Jaume I (UJI). Departament de Química Inorgànica i Orgànica DOI: https://doi.org/10.2436/20.2003.01.144 Keywords: Cysteine proteases, inhibitors, peptidomimetics Abstract Small molecules acting as cysteine protease inhibitors have been designed according to the enzyme’s mechanism of action. These inhibitors have been synthesized and tested against parasitic cysteine proteases related to infectious diseases. The inhibitors display a general structure with two parts: a peptidomimetic part recognized by the active center and an electrophilic group (“warhead”) which is reactive with cysteine. The reactivity of the warhead with the cysteine thiol determines the inhibition kinetics. Downloads Download data is not yet available. Author Biography Florenci V. González, Universitat Jaume I (UJI). Departament de Química Inorgànica i Orgànica Florenci V. González és doctor en química per la Universitat Jaume I (UJI) des del 1995. Els anys 1997-1998 va fer una estada postdoctoral a la Universitat d’Indiana amb el professor William R. Roush, i el 1999, a la Universitat Estatal de Colorado amb el professor Robert M. Williams. El 2001 va ser professor titular de l’UJI i des d’enguany és catedràtic de química orgànica d’aquesta mateixa universitat. Els seus camps d’investigació són el descobriment de fàrmacs i el desenvolupament de noves reaccions químiques. Ha publicat més de seixanta articles d’investigació i ha estat professor visitant a la Universitat de Bath i a la Northwestern University. Downloads PDF (Català) Published 2023-12-15 Issue No. 22 (2023) Section Articles License The intellectual property of articles belongs to the respective authors. On submitting articles for publication to the journal Revista de la Societat Catalana de Química, authors accept the following terms:Authors assign to Catalan Society of Chemistry (a subsidiary of Institut d’Estudis Catalans) the rights of reproduction, communication to the public and distribution of the articles submitted for publication to Revista de la Societat Catalana de Química.Authors answer to Catalan Society of Chemistry for the authorship and originality of submitted articles.Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles.Catalan Society of Chemistry declines all liability for the possible infringement of intellectual property rights by authors.The contents published in the journal, unless otherwise stated in the text or in the graphic material, are subject to a Creative Commons Attribution-NonCommercial-NoDerivs (by-nc-nd) 3.0 Spain licence, the complete text of which may be found at http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Consequently, the general public is authorised to reproduce, distribute and communicate the work, provided that its authorship and the body publishing it are acknowledged, and that no commercial use and no derivative works are made of it.The journal is not responsible for the ideas and opinions expressed by the authors of the published articles.
