Recent developments in nickel-catalyzed cross-coupling reactions via C–O functionalization

Authors

  • Carlota Odena Institut Català d’Investigació Química (ICIQ)
  • Laura Talavera Institut Català d’Investigació Química (ICIQ)
  • Ruben Martin Institut Català d’Investigació Química (ICIQ)

Keywords:

Cross-coupling reactions, nickel catalysis, C−O bond cleavage.

Abstract

The use of phenol and carboxylic acid derivatives as electrophiles in nickel-catalyzed cross-coupling reactions has undergone exponential growth in the last two decades, becoming a powerful synthetic tool for forging C–C and C–heteroatom bonds. This review summarizes the most recent developments in the utilization of non-particularly activated C−O electrophiles such as carbamates, pivalates, methyl ethers and aryl methyl esters.


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Author Biographies

Carlota Odena, Institut Català d’Investigació Química (ICIQ)

Carlota Odena received her B.Sc. degree in Chemistry (2018) and her M.Sc. degree in Synthesis, Catalysis and Molecular Design (2019) from Universitat Rovira i Virgili (URV) and ICIQ, and wrote both her Bachelor’s degree and Master’s theses under the supervision of Prof. Mónica H. Pérez-Temprano at the Institut Català d’Investigació Química (ICIQ). In October 2019 she began her doctoral studies under the supervision of Prof. Ruben Martin at ICIQ, working on the synthesis of nickel complexes for mechanistic understandings.

1 Institut Català d’Investigació Química (ICIQ)
2 Universitat Rovira i Virgili. Departament de Química Analítica i Química Orgànica

Laura Talavera, Institut Català d’Investigació Química (ICIQ)

Laura Talavera received her B.Sc. degree in Chemistry (2015) from Universitat Autònoma de Barcelona (UAB) and her M.Sc. degrees (2016 and 2017) from UAB and Esteve Química, S.A. She then moved to the United Kingdom to work as a scientist at Aptuit LLC. In October 2019, she joined Prof. Ruben Martin’s group at ICIQ, where her research is focused on the area of C−O bond-activation and catalytic functionalization of olefin feedstocks via functionalization of remote C−sp3 sites.

1 Institut Català d’Investigació Química (ICIQ)
2 Universitat Rovira i Virgili. Departament de Química Analítica i Química Orgànica

Ruben Martin, Institut Català d’Investigació Química (ICIQ)

Ruben Martin conducted his undergraduate studies at the Universitat de Barcelona (UB). He then received his PhD in 2003 from UB under the guidance of Prof. Antoni Riera. In 2004, he moved to the Max-Planck Institut für Kohlenforschung as a Humboldt postdoctoral fellow with Prof. Alois Fürstner. In 2005, he undertook further postdoctoral studies at MIT with Prof. Stephen L. Buchwald as an MEC-Fulbright fellow. In September 2008, he initiated his independent career as an assistant professor at the ICIQ (Tarragona). In July 2013, he was promoted to associate professor and subsequently to ICREA research professor. His research is focused on the development of new metal-catalyzed activation technologies of particularly strong s-bonds.

1 Institut Català d’Investigació Química (ICIQ)
2 Institució Catalana de Recerca i Estudis Avançats (ICREA)

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Issue

No. 20 (2021)

Section

Articles

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