Estimation of the octanol-water distribution coefficient of acidic compounds by a microemulsion electrokinetic chromatography system

Authors

  • Alejandro Fernández-Pumarega Universitat de Barcelona
  • Susana Amézqueta Universitat de Barcelona
  • Elisabet Fuguet Universitat de Barcelona
  • Martí Rosés Universitat de Barcelona

Keywords:

Capillary electrophoresis, MEEKC, log Do/w, lipophilicity, microemulsion electrokinetic chromatography, microemulsion.

Abstract

Lipophilicity is a key property in the physicochemical characterization of bioactive substances, since it is linked to the ability of the compounds to penetrate cell membranes. The most usual procedure for determining the octanol-water distribution coefficient is the shake-flask method, which is tedious and time-consuming. Due to these drawbacks, alternative methods have been developed such as microemulsion electrokinetic chromatography (MEEKC), which is able to estimate this parameter for neutral substances. In this paper, the applicability of the method for partially ionized acidic substances is demonstrated.

Keywords: Capillary electrophoresis, MEEKC, log Do/w, lipophilicity, microemulsion electrokinetic chromatography, microemulsion.

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Issue

No. 17 (2018)

Section

Articles

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