Estimation of the octanol-water distribution coefficient of acidic compounds by a microemulsion electrokinetic chromatography system Authors Alejandro Fernández-Pumarega Universitat de Barcelona Susana Amézqueta Universitat de Barcelona Elisabet Fuguet Universitat de Barcelona Martí Rosés Universitat de Barcelona Keywords: Capillary electrophoresis, MEEKC, log Do/w, lipophilicity, microemulsion electrokinetic chromatography, microemulsion. Abstract Lipophilicity is a key property in the physicochemical characterization of bioactive substances, since it is linked to the ability of the compounds to penetrate cell membranes. The most usual procedure for determining the octanol-water distribution coefficient is the shake-flask method, which is tedious and time-consuming. Due to these drawbacks, alternative methods have been developed such as microemulsion electrokinetic chromatography (MEEKC), which is able to estimate this parameter for neutral substances. In this paper, the applicability of the method for partially ionized acidic substances is demonstrated.Keywords: Capillary electrophoresis, MEEKC, log Do/w, lipophilicity, microemulsion electrokinetic chromatography, microemulsion. Downloads Download data is not yet available. Downloads PDF (Català) Issue No. 17 (2018) Section Articles License The intellectual property of articles belongs to the respective authors. On submitting articles for publication to the journal Revista de la Societat Catalana de Química, authors accept the following terms:Authors assign to Catalan Society of Chemistry (a subsidiary of Institut d’Estudis Catalans) the rights of reproduction, communication to the public and distribution of the articles submitted for publication to Revista de la Societat Catalana de Química.Authors answer to Catalan Society of Chemistry for the authorship and originality of submitted articles.Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles.Catalan Society of Chemistry declines all liability for the possible infringement of intellectual property rights by authors.The contents published in the journal, unless otherwise stated in the text or in the graphic material, are subject to a Creative Commons Attribution-NonCommercial-NoDerivs (by-nc-nd) 3.0 Spain licence, the complete text of which may be found at http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Consequently, the general public is authorised to reproduce, distribute and communicate the work, provided that its authorship and the body publishing it are acknowledged, and that no commercial use and no derivative works are made of it.The journal is not responsible for the ideas and opinions expressed by the authors of the published articles.
