New synthetic route to N-arylated pyridazinones from aryldiazonium salts Authors Daniel Cassú Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Ouissam El Bakouri Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Miquel Solà Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Anna Pla-Quintana Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Anna Roglans Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Keywords: N-arylated pyridazinones, aryldiazonium salts, DFT calculations. Abstract Pyridazinones are organic compounds that are commonly found in drugs, pesticides, and natural products with biological activity. To date, a considerable number of synthetic routes to obtain pyridazinones have been published although only a few have described efficient pathways to prepare N-arylated pyridazinones. In contrast to methods found in literature in which strong reaction conditions or metallic catalysts are employed, this study proposes a new route to obtain N-arylated pyridazinones using aryldiazonium salts and furan derivatives in mild reaction conditions with water as the solvent. Diazonium salts are highly reactive compounds and so their use results in an important gain in terms of the efficiency of the process. The reaction mechanism is elucidated by DFT calculations and confirmed by empirical tests.Keywords: N-arylated pyridazinones, aryldiazonium salts, DFT calculations. Downloads Download data is not yet available. Author Biography Daniel Cassú, Universitat de Girona. Institut de Química Computacional i Catàlisi (IQCC) Universitat de Girona. Departament de Química Downloads PDF (Català) Issue No. 15 (2016) Section Articles License The intellectual property of articles belongs to the respective authors. On submitting articles for publication to the journal Revista de la Societat Catalana de Química, authors accept the following terms:Authors assign to Catalan Society of Chemistry (a subsidiary of Institut d’Estudis Catalans) the rights of reproduction, communication to the public and distribution of the articles submitted for publication to Revista de la Societat Catalana de Química.Authors answer to Catalan Society of Chemistry for the authorship and originality of submitted articles.Authors are responsible for obtaining permission for the reproduction of all graphic material included in articles.Catalan Society of Chemistry declines all liability for the possible infringement of intellectual property rights by authors.The contents published in the journal, unless otherwise stated in the text or in the graphic material, are subject to a Creative Commons Attribution-NonCommercial-NoDerivs (by-nc-nd) 3.0 Spain licence, the complete text of which may be found at http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.en. Consequently, the general public is authorised to reproduce, distribute and communicate the work, provided that its authorship and the body publishing it are acknowledged, and that no commercial use and no derivative works are made of it.The journal is not responsible for the ideas and opinions expressed by the authors of the published articles.
