Constraining conformational space: helical peptides as conveyors of chiral information at a distance

Authors

  • Jordi Solà Institut de Química Avançada de Catalunya (IQAC-CSIC)

Keywords:

Conformació, quiralitat, hèlice, pèptid, transmissió.

Abstract

Communication of information – for example, signal transduction through membrane receptors – is a key process in biological functions. This communication is achieved by conformational changes induced by the reversible binding of a messenger. In artificial systems, the available conformational space of certain macromolecules can be sometimes controlled by a series of intramolecular interactions. The control and propagation of the conformation allows the communication of information along the structure. In helical molecules, the control and propagation of the screw sense allows a read-off of a chiral influence even at a distance of 4 nm.

Keywords: Conformation, chirality, helix, peptide, communication of information.

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Issue

No. 14 (2015)

Section

Articles

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