Metallacarboranes and molecular biology: the striking interaction of two apparently independent worlds

Authors

  • Màrius Tarrés Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)
  • Elisabetta Canetta Cardiff University. School of Biosciences
  • Clara Viñas Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)
  • Francesc Teixidor Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)
  • Adrian J. Harwood Cardiff University. School of Biosciences

Keywords:

Metallacarboranes, synthetic membranes, self-assembly, cellular division, cellular proliferation, Raman microscopy.

Abstract

Metallacarborane’s self-assembly has been recently widely investigated. Its ability to form monolayer membranes led us to study the interaction of these synthetic membranes with biological membranes. This work evidences that the cobaltibisdicarbollide anion, [3,3’-Co(C2B9H11)2]− (COSAN), and its di-iodinated derivative, [3,3’-Co(8-I-C2B9H10)2]− (I2-COSAN), can interact with biological membranes and cross them, accumulating inside living cells. When applying these compounds to different cells in culture, complete but reversible cell proliferation suppression is induced, with a total recovery of the cell division activity after removal of the metallacarborane from the media.

Keywords: Metallacarboranes, synthetic membranes, self-assembly, cellular division, cellular proliferation, Raman microscopy.

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Issue

No. 13 (2014)

Section

Articles

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