Discovering new arene-catalyzed lithiations

Autores/as

  • Miguel Yus Institute of Organic Synthesis, University of Alacant

Resumen

Arene-catalyzed lithiation is a useful and versatile methodology that promotes lithiation processes under very mild reaction conditions. This report presents recent results in the application of this technology, mainly in the following fields: (a) intramolecular carbolithiation vs. ring-opening in lithiomethylcycloalkanes; (b) the generation of dilithium synthons as precursors of bicyclic and spiro ethers, major units in biological active natural products; (c) general deprotection of different oxygen-, sulfur-, and nitrogen-containing protected compounds under non-hydrolytic conditions; and (d) the preparation of nickel nanoparticles and their application in carbon-carbon and carbon-nitrogen bond formation reactions.

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