Molecular epidemiology of methicillin-resistant Staphylococcus aureus in a university hospital in northwestern Spain

Autores/as

  • Jaime Ariza-Miguel Institute of Agricultural Technology of Castilla y León, Valladolid
  • Marta Hernández Institute of Agricultural Technology of Castilla y León, Valladolid
  • Isabel Fernández-Natal University Hospital of Leon, Leon, Spain. Institute of Biomedicine (IBIOMED), University of Leon, Leon.
  • David Rodríguez-Lázaro Microbiology Section. Faculty of Sciences University of Burgos

Palabras clave:

methicillin-resistant Staphylococcus aureus (MRSA), clonal population, molecular epidemiology, multilocus sequence typing

Resumen

Continuous monitoring of methicillin-resistant Staphylococcus aureus (MRSA) is necessary to understand the clonal evolution of successful lineages. In this study, we identifi ed the MRSA clones circulating in a Spanish hospital during a 2-year period, assessed their relationship with antimicrobial resistance profi les, and investigated the presence of the emerging community-associated and livestock-associated MRSA lineages (CA-MRSA, LA-MRSA). CC5-MRSA-IV isolates were the most frequently recovered, which supports the previously reported prevalence of this clone in Spanish hospitals. We observed ST125 isolates that harbored specifi c cassette chromosome recombinase (ccr) gene elements of the staphylococcal cassette chromosome mec (SCCmec) types IV and VI. That clone, which was fi rst detected only recently, has increased resistance to erythromycin. Furthermore, 94% of the infections were caused by non-multiresistant isolates. Neither CA-MRSA nor LA-MRSA isolates were observed. These fi ndings, along with related events over the last decade, suggest the establishment of a clonal endemic population in the Spanish clinical environment. [Int Microbiol 2014; 17(3):149-157]

Keywords: methicillin-resistant Staphylococcus aureus (MRSA) · clonal population · molecular epidemiology · multilocus sequence typing

Biografía del autor/a

Jaime Ariza-Miguel, Institute of Agricultural Technology of Castilla y León, Valladolid




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Número

Vol. 17 Núm. 3 (2014)

Sección

Research Articles

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