Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease Authors Sara B. Hernández Department of Genetics, School of Biology, University of Sevilla, Sevilla Juan A. Ayala Center of Molecular Biology Severo Ochoa, CSIC-Autonomous University of Madrid, Cantoblanco Gadea Rico-Pérez National Center of Biotechnology (CNB)-CSIC, Madrid Francisco García-del Portillo National Center of Biotechnology (CNB)-CSIC, Madrid Josep Casadesús Departamento de Genética, Facultad de Biología Universidad de Sevilla Keywords: Salmonella, bile, Prc protease, peptidoglycan, penicillin-binding proteins Abstract Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppressesbile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in thewild type. Changes in the activity of penicillin binding proteins PBP3, PBP4, PBP5/6 and PBP7 are detected in a Prc-background, suggesting that peptidoglycan remodeling might contribute to bile resistance. [Int Microbiol 2013; 16(2):87-92]Keywords: Salmonella; bile; Prc protease; peptidoglycan; penicillin-binding proteins Downloads PDF Issue Vol. 16 No. 2 (2013) Section Research Articles License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. The corresponding author signs for and accepts responsability for releasing this material and will act on behalf of any and all coauthors regarding the editorial review and publication process.If an article is accepted for publication in International Microbiology, the authors (or other copyright holder) must transfer to the journal the right–not exclusive–to reproduce and distribute the article including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. Nevertheless, all article in International Microbiology will be available on the Internet to any reader at no cost. The journal allows users to freely download, copy, print, distribute, search, and link to the full text of any article, provided the authorship and source of the published article is cited. The copyright owner's consent does not include copying for new works, or resale. In these cases, the specific written permission of International Microbiology must first be obtained.Authors are requested to create a link to the published article on the journal's website. The link must be accompanied by the following text: "The original publication is available on LINK at <http://www.im.microbios.org>. Please use the appropiate URL for the article in LINK. Articles disseminated via LINK are indexed, abstracted, and referenced by many abstracting and information services, bibliographic networks, subscription agencies, library networks, and consortia.
