ABC transporters in the protozoan parasite Leishmania

Autors/ores

  • José M. Pérez-Victoria Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain
  • Adriana Parodi-Talice Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain
  • Cristina Torres Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain
  • Francisco Gamarro Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain
  • Santiago Castanys Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain

Paraules clau:

leishmania, ABC transporters, drug resistance, P-glycoproteins, MDR modulators

Resum

ATP-binding cassette ABC) transporters constitute one of the biggest and most conserved protein families in the evolutionary scale. Many of them are of enormous clinical relevance, due to their relationship with genetic diseases and drug resistance during the treatment of cancer and infectious diseases. Leishmaniasis is a major and globally widespread group of parasitic diseases, whose treatment has been complicated by the expansion of resistance to conventional drugs. Here, we review the current knowledge about ABC transporters in Leishmania spp, with special attention to their relationship with the drug-resistance phenotype.

Descàrregues

Publicat

2010-03-12

Número

Vol. 4 Núm. 3 (2001)

Secció

Review Articles

Llicència

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