Genomic Plasticity of Vibrio cholerae

Autors/ores

  • Jose Antonio Escudero
  • Didier Mazel

Paraules clau:

ibrio cholerae, genome plasticity, superintegron

Resum

Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, a
disease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. cholerae
is a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insects
and crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. In
this review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of its
genome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-cost
memory of adaptive functions, allowing V. cholerae to adapt rapidly.

Biografies de l'autor/a

Jose Antonio Escudero

1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France
2. CNRS, UMR3525, Paris, France
3. Molecular Basis of Adaptation, Departamento de Sanidad Animal, Facultad de Veterinaria,
Universidad Complutense de Madrid, Madrid, Spain
4. VISAVET Health Surveillance Centre.
Universidad Complutense Madrid. Avenida Puerta de Hierro, s/n. 28040 Madrid. Spain

Didier Mazel

1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France
2. CNRS, UMR3525, Paris, France

Descàrregues

Publicat

2018-02-27

Número

Vol. 20 Núm. 3 (2017)

Secció

Research Reviews

Llicència

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