Bacteriological conversion in twenty urinary tuberculosis patients treated with ofloxacin, rifampin and isoniazid: a 10-year follow-up study

Autors/ores

  • J. Alberte Castiñeiras Microbiología, Hospital del Río Hortega, Valladolid, Spain
  • P. Pérez-Pascual Microbiología, Hospital del Río Hortega, Valladolid, Spain
  • Estébanez J. Zarranz Servicio de Urología, Hospital del Río Hortega, Valladolid, Spain
  • P. Della-Latta Clinical Microbiology Service, Columbia-Presbyterian Medical Center, New York, USA
  • A. Herreras Aventis Pharma SA, Madrid, Spain

Paraules clau:

tuberculosis treatment, urinary tuberculosis, ofloxacin, tuberculosis conversion

Resum

Twenty patients withuri nary tuberculosis were treated withofloxac in (200 mg/day, 6 months), rifampin (600 mg/day, 3 months) and isoniazid (300 mg/day, 3 months) between 1989 and 1990. All patients were new cases, diagnosed by observation and/or isolation of Mycobacterium tuberculosis in one of the three morning urine samples. Bacteriological culture conversion (negativization) was assessed as a clinical guide of efficacy, comparing it, as the only parameter, against a control group (150 patients) withurina ry tuberculosis who received conventional therapy. Bacteriological follow-up studies were performed in bothgroups monthly for 6 months, then again 6 months later and then every year for 10 years after completion of treatment. In the 20 patients, the initial culture was positive with over 100 colonies per culture (>50%); the smear was positive in 45% of the patients (most were 2+). All strains were susceptible to rifampin, isoniazid and ofloxacin. Two patients discontinued treatment. Beginning withth e first monthof treatment, the bacteriological conversion was 100%, 89.5% and 100% in the remaining controls. In the control group, which received conventional treatment, the conversion was: 90%, 87%, 93% and 100% in the remaining controls. Treatment withofloxacin resulted in a bacteriological conversion similar to that following conventional treatment (p>0.05, Fisher’s exact test). After 10 years of patient follow-up, we conclude that ofloxacin, in combination withrifampin and isoniazid (bothfor 3 months only is effective against M. tuberculosis, providing satisfactory bacteriological and clinical efficacy.

Biografies de l'autor/a

J. Alberte Castiñeiras, Microbiología, Hospital del Río Hortega, Valladolid, Spain

Microbiología, Hospital del Río Hortega, Valladolid, Spain

P. Pérez-Pascual, Microbiología, Hospital del Río Hortega, Valladolid, Spain

Microbiología, Hospital del Río Hortega, Valladolid, Spain

Estébanez J. Zarranz, Servicio de Urología, Hospital del Río Hortega, Valladolid, Spain

Servicio de Urología, Hospital del Río Hortega, Valladolid, Spain

P. Della-Latta, Clinical Microbiology Service, Columbia-Presbyterian Medical Center, New York, USA

Clinical Microbiology Service, Columbia-Presbyterian Medical Center, New York, USA

A. Herreras, Aventis Pharma SA, Madrid, Spain

Aventis Pharma SA, Madrid, Spain

Descàrregues

Publicat

2010-09-21

Número

Secció

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