ABC transporters in the protozoan parasite Leishmania Authors José M. Pérez-Victoria Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain Adriana Parodi-Talice Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain Cristina Torres Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain Francisco Gamarro Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain Santiago Castanys Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Granada, Spain Keywords: leishmania, ABC transporters, drug resistance, P-glycoproteins, MDR modulators Abstract ATP-binding cassette ABC) transporters constitute one of the biggest and most conserved protein families in the evolutionary scale. Many of them are of enormous clinical relevance, due to their relationship with genetic diseases and drug resistance during the treatment of cancer and infectious diseases. Leishmaniasis is a major and globally widespread group of parasitic diseases, whose treatment has been complicated by the expansion of resistance to conventional drugs. Here, we review the current knowledge about ABC transporters in Leishmania spp, with special attention to their relationship with the drug-resistance phenotype. Downloads PDF Published 2010-03-12 Issue Vol. 4 No. 3 (2001) Section Review Articles License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. The corresponding author signs for and accepts responsability for releasing this material and will act on behalf of any and all coauthors regarding the editorial review and publication process.If an article is accepted for publication in International Microbiology, the authors (or other copyright holder) must transfer to the journal the right–not exclusive–to reproduce and distribute the article including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. Nevertheless, all article in International Microbiology will be available on the Internet to any reader at no cost. The journal allows users to freely download, copy, print, distribute, search, and link to the full text of any article, provided the authorship and source of the published article is cited. The copyright owner's consent does not include copying for new works, or resale. In these cases, the specific written permission of International Microbiology must first be obtained.Authors are requested to create a link to the published article on the journal's website. The link must be accompanied by the following text: "The original publication is available on LINK at <http://www.im.microbios.org>. Please use the appropiate URL for the article in LINK. Articles disseminated via LINK are indexed, abstracted, and referenced by many abstracting and information services, bibliographic networks, subscription agencies, library networks, and consortia.
