Genomic Plasticity of Vibrio cholerae Authors Jose Antonio Escudero Didier Mazel Keywords: ibrio cholerae, genome plasticity, superintegron Abstract Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, adisease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. choleraeis a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insectsand crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. Inthis review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of itsgenome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-costmemory of adaptive functions, allowing V. cholerae to adapt rapidly. Author Biographies Jose Antonio Escudero 1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France2. CNRS, UMR3525, Paris, France3. Molecular Basis of Adaptation, Departamento de Sanidad Animal, Facultad de Veterinaria,Universidad Complutense de Madrid, Madrid, Spain4. VISAVET Health Surveillance Centre.Universidad Complutense Madrid. Avenida Puerta de Hierro, s/n. 28040 Madrid. Spain Didier Mazel 1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France2. CNRS, UMR3525, Paris, France Downloads PDF Published 2018-02-27 Issue Vol. 20 No. 3 (2017) Section Research Reviews License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. The corresponding author signs for and accepts responsability for releasing this material and will act on behalf of any and all coauthors regarding the editorial review and publication process.If an article is accepted for publication in International Microbiology, the authors (or other copyright holder) must transfer to the journal the right–not exclusive–to reproduce and distribute the article including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. Nevertheless, all article in International Microbiology will be available on the Internet to any reader at no cost. The journal allows users to freely download, copy, print, distribute, search, and link to the full text of any article, provided the authorship and source of the published article is cited. The copyright owner's consent does not include copying for new works, or resale. In these cases, the specific written permission of International Microbiology must first be obtained.Authors are requested to create a link to the published article on the journal's website. The link must be accompanied by the following text: "The original publication is available on LINK at <http://www.im.microbios.org>. Please use the appropiate URL for the article in LINK. Articles disseminated via LINK are indexed, abstracted, and referenced by many abstracting and information services, bibliographic networks, subscription agencies, library networks, and consortia.