Genomic Plasticity of Vibrio cholerae

Authors

  • Jose Antonio Escudero
  • Didier Mazel

Keywords:

ibrio cholerae, genome plasticity, superintegron

Abstract

Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, adisease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. choleraeis a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insectsand crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. Inthis review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of itsgenome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-costmemory of adaptive functions, allowing V. cholerae to adapt rapidly.

Author Biographies

Jose Antonio Escudero

1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France2. CNRS, UMR3525, Paris, France3. Molecular Basis of Adaptation, Departamento de Sanidad Animal, Facultad de Veterinaria,Universidad Complutense de Madrid, Madrid, Spain4. VISAVET Health Surveillance Centre.Universidad Complutense Madrid. Avenida Puerta de Hierro, s/n. 28040 Madrid. Spain

Didier Mazel

1. Institut Pasteur, Unité de Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France2. CNRS, UMR3525, Paris, France

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Published

2018-02-27

Issue

Vol. 20 No. 3 (2017)

Section

Research Reviews

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