Detection of the aminoglycosidestreptothricin resistance gene cluster ant(6)-sat4-aph(3´)-III in commensal viridans group streptococci Authors Paula Cerdá Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Pilar Goñi Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Leticia Millán Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Carmen Rubio Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Microbiology Service, Lozano Blesa University Clinic Hospital, Zaragoza, Spain Rafael Gómez-Lus Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Keywords: viridans group streptococci, aminoglycosides, streptothricin, resistance genes Abstract High-level aminoglycoside resistance was assessed in 190 commensal erythromycin-resistant α-hemolytic streptococcal strains. Of these, seven were als aminoglycoside-resistant: one Streptococcus mitis strain was resistant to high levels of kanamycin and carried the aph(3´)-III gene, four S. mitis strains were resistant to high levels of streptomycin and lacked aminoglycoside-modifying enzymes, and two S. oralis strains that were resistant to high levels of kanamycin and streptomycin harbored both the aph(3´)-III and the ant(6) genes. The two S. oralis strains also carried the ant(6)-sat4-aph(3´´)-III aminoglycoside-streptothricin resistance gene cluster, but it was not contained in a Tn5405-like structure. The presence of this resistance gene cluster in commensal streptococci suggests an exchange of resistance genes between these bacteria and enterococci or staphylococci. [Int Microbiol 2007; 10(1):57-60] Author Biographies Paula Cerdá, Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Pilar Goñi, Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Leticia Millán, Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Carmen Rubio, Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Microbiology Service, Lozano Blesa University Clinic Hospital, Zaragoza, Spain Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Microbiology Service, Lozano Blesa University Clinic Hospital, Zaragoza, Spain Rafael Gómez-Lus, Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Department of Microbiology, Preventive Medicine and Public Health, Zaragoza University School of Medicine, Spain Downloads PDF Published 2010-01-27 Issue Vol. 10 No. 1 (2007) Section Research Notes License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. 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