Candida albicans: genetics, dimorphism and pathogenicity

Authors

  • Gloria Molero Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Rosalía Díez-Orejas Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Federico Navarro-García Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Lucía Monteoliva Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Jesús Pla Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Concha Gil Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Miguel Sánchez-Pérez Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • César Nombela Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain

Keywords:

Candida albicans, dimorphism, yeast genetics, morphogenesis, yeast pathogenicity

Abstract

Candida albicans is a dimorphic fungus that causes severe opportunistic infections in humans. Recent advances in molecular biology techniques applied to this organism (transformation systems, gene disruption strategies, new reporter systems, regulatable promoters) allow a better knowledge of both the molecular basis of dimorphism and the role of specific genes in Candida morphogenesis. These same molecular approaches together with the development of appropriate experimental animal models to analyze the virulence of particular mutants, may help to understand the molecular basis of Candida virulence.

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Published

2010-03-18

Issue

Vol. 1 No. 1 (1998)

Section

Research Articles

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