Divergent functional roles of D-amino acids secreted by Vibrio cholerae Authors Felipe Cava Keywords: Vibrio cholerae, D-amino acids, cell wall, D-methionine, D-arginine Abstract The L-forms of amino acids are used in all kingdoms of life to synthesize proteins. However, the bacterium Vibriocholerae, the causative agent of cholera, produces D-amino acids which are released to the environment at millimolar concentrations.We baptized these D-amino acids as non-canonical D-amino acids (NCDAAs) since they are different from those (i.e.D-alanine and D-glutamate) normally present in the bacterial cell wall. In V. cholerae, production of NCDAAs relies on the BsrVenzyme, a periplasmic broad spectrum racemase. BsrV multispecific activity, produces of a wide range of distinct D-amino acids.Using a combination of genetics and molecular physiology approaches we have demonstrated that NCDAAs target different cellularprocesses which may function as part of a cooperative strategy in vibrio communities to protect non-producing members fromcompeting bacteria. Because NCDAA production is widespread in bacteria, we anticipate that NCDAAs are relevant modulatorsof microbial subpopulations in diverse ecosystems. Author Biography Felipe Cava The laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology. Umeå University.90187. Umeå. Sweden. Ph: +46(0) 90 785 6755. Downloads PDF Published 2018-02-27 Issue Vol. 20 No. 3 (2017) Section Research Reviews License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. The corresponding author signs for and accepts responsability for releasing this material and will act on behalf of any and all coauthors regarding the editorial review and publication process.If an article is accepted for publication in International Microbiology, the authors (or other copyright holder) must transfer to the journal the right–not exclusive–to reproduce and distribute the article including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. Nevertheless, all article in International Microbiology will be available on the Internet to any reader at no cost. The journal allows users to freely download, copy, print, distribute, search, and link to the full text of any article, provided the authorship and source of the published article is cited. The copyright owner's consent does not include copying for new works, or resale. In these cases, the specific written permission of International Microbiology must first be obtained.Authors are requested to create a link to the published article on the journal's website. The link must be accompanied by the following text: "The original publication is available on LINK at <http://www.im.microbios.org>. Please use the appropiate URL for the article in LINK. Articles disseminated via LINK are indexed, abstracted, and referenced by many abstracting and information services, bibliographic networks, subscription agencies, library networks, and consortia.