Bacterial pathogenesis as an imperfect symbiosis
Abstract
Human-adapted bacterial pathogens such as Salmonella enterica serovar Typhi, Helicobacter pylori, and Mycobacterium tuberculosis cause acute infections and also latent, asymptomatic infections. During latent infection the pathogen undergoes self-attenuation of virulence, a lifestyle that reduces the impact of infection on host fitness. Evolutionary strategies of this kind may drive certain bacterial pathogens towards commensalism.
Keywords: evolution · human pathogens · host susceptibility · symbiosis