Dynamics of CaCdc10, a septin of Candida albicans, in living cells and during infection Authors Alberto González-Novo Institute for Biochemical Microbiology, University of Salamanca-CSIC, Spain Javier Jiménez Institute for Biochemical Microbiology, University of Salamanca-CSIC, Spain M. Jesús García Institute for Biochemical Microbiology, University of Salamanca-CSIC, Spain Inmaculada Ríos-Serrano Microbiology Department, Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, Spain Jesús Pla Microbiology Department, Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, Spain Antonio Jiménez Medicine Department, Faculty of Medicine, University of Salamanca, Spain Miguel Sánchez Pérez Institute for Biochemical Microbiology, University of Salamanca-CSIC, Spain Keywords: Candida albicans, dimorphism, septin Cdc10, systemic infection Abstract The morphogenetic program in the pathogenic fungus Candida albicans , including the dimorphic transition, is an interesting field of study, not only because it is absent in the commonly used model yeast Saccharomyces cerevisiae, but because of the close relationship between hyphal development and virulence of C. albicans. We studied one of the most important aspects of fungal morphogenesis-the septin ring–in C. albicans. By using a fusion construct to green fluorescent protein (GFP), the subcellular localization and dynamics of C. albicans Cdc10 in the different morphologies that this fungus is able to adopt was identified. The localization features reached were contrasted and compared with the results obtained from Candida cells directly extracted from an animal infection model under environmental conditions as similar as possible to the physiological conditions encountered by C. albicans during host infection. [Int Microbiol 2004; 7(2):105–112] Downloads PDF Published 2010-02-28 Issue Vol. 7 No. 2 (2004) Section Research Articles License Submission of a manuscript to International Microbiology implies: that the work described has not been published before, including publication in the World Wide Web (except in the form of an Abstract or as part of a published lecture, review, or thesis); that it is not under consideration for publication elsewhere; that all the coauthors have agreed to its publication. The corresponding author signs for and accepts responsability for releasing this material and will act on behalf of any and all coauthors regarding the editorial review and publication process.If an article is accepted for publication in International Microbiology, the authors (or other copyright holder) must transfer to the journal the right–not exclusive–to reproduce and distribute the article including reprints, translations, photographic reproductions, microform, electronic form (offline, online) or any other reproductions of similar nature. Nevertheless, all article in International Microbiology will be available on the Internet to any reader at no cost. The journal allows users to freely download, copy, print, distribute, search, and link to the full text of any article, provided the authorship and source of the published article is cited. The copyright owner's consent does not include copying for new works, or resale. In these cases, the specific written permission of International Microbiology must first be obtained.Authors are requested to create a link to the published article on the journal's website. The link must be accompanied by the following text: "The original publication is available on LINK at <http://www.im.microbios.org>. Please use the appropiate URL for the article in LINK. Articles disseminated via LINK are indexed, abstracted, and referenced by many abstracting and information services, bibliographic networks, subscription agencies, library networks, and consortia.
