International Microbiology, Vol 1, No 3 (1998)

Molecular mechanisms of Salmonella invasion: the type III secretion system of the pathogenicity island 1

Mónica Suárez, Holger Rüssmann


Salmonella spp. are facultative intracellular pathogens which are able to enter into non-phagocytic cells as an essential step in their pathogenic life cycle. The majority of the molecular determinants involved in this entry process are encoded in a pathogenicity island located at the centisome 63 of the bacterial chromosome, and belong to a specialized protein secretion system termed “type III” or “contactdependent”. This secretion system is used by Salmonella spp. and several other bacterial pathogens to translocate bacterial effector proteins into the eukaryotic cell. Thus, a bidirectional biochemical cross-talk with the host cell is initiated, which leads to several responses such as membrane ruffling, bacterial internalization and the activation of various transcription factors.

Full Text: PDF

Sello de Calidad FECYT



5-year Impact Factor of International Microbiology is 2,10.

The journal is covered in several leading abstracting and indexing databases, including the following ones: AFSA Marine Biotechnology Abstracts; Biological Abstracts; Biotechnology Research Abstracts; BIOSIS Previews; CAB Abstracts; Chemical Abstracts; Current Contents–Agriculture, Biology & Environmental Sciences; EBSCO; Embase; Food Science and Technology Abstracts; Google Scholar; IEDCYT; IBECS; Latíndex; MedBioWorld; PubMed; SciELO-Spain; Science Citation Index Expanded; Scopus


Creative Commons License

This work, including photographs and other illustrations, unless the contrary is indicated, is subject to an Attributions–Non-Commercial–ShareAlike 3.0 Creative Commons License, the full text of which can be consulted at You are free to share, copy, distribute and transmit the work provided that the author is credited and reuse of the material is restricted to non-commercial purposes only and that if you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one. 


Copyright ® 2013 by Spanish Society for Microbiology (SEM)