International Microbiology, Vol 20, No 3 (2017)

Coordination between replication, segregation and cell division in multi-chromosomal bacteria: lessons from Vibrio cholerae

Elena Espinosa, François-Xavier Barre, Elisa Galli

Abstract


Bacteria display a highly flexible cell cycle in which cell division can be temporally disconnected from the replication/
segregation cycle of their genome. The accuracy of genetic transmission is enforced by restricting the assembly of the
cell division apparatus to the low DNA-density zones that develop between the regularly spaced nucleoids originating from the
concurrent replication and segregation of genomic DNA. In most bacteria, the process is simplified because the genome is encoded
on a single chromosome. This is notably the case in Escherichia coli, the most well studied bacterial model organism. However,
~10% of bacteria have domesticated horizontally acquired mega-plasmids into extra-numerous chromosomes. Most of our current
knowledge on the cell cycle regulation of multi-chromosomal species derives from the study of replication, segregation and cell
division in Vibrio cholerae, the agent of the deadly epidemic human diarrheal disease cholera. A nicety of this model is that it is
closely related to E. coli in the phylogenetic tree of bacteria. Here, we review recent findings on the V. cholerae cell cycle in the
context of what was previously known on the E. coli cell cycle.

Full Text: PDF

Sello de Calidad FECYT

 

 

5-year Impact Factor of International Microbiology is 2,10.

The journal is covered in several leading abstracting and indexing databases, including the following ones: AFSA Marine Biotechnology Abstracts; Biological Abstracts; Biotechnology Research Abstracts; BIOSIS Previews; CAB Abstracts; Chemical Abstracts; Current Contents–Agriculture, Biology & Environmental Sciences; EBSCO; Embase; Food Science and Technology Abstracts; Google Scholar; IEDCYT; IBECS; Latíndex; MedBioWorld; PubMed; SciELO-Spain; Science Citation Index Expanded; Scopus

 

Creative Commons License

This work, including photographs and other illustrations, unless the contrary is indicated, is subject to an Attributions–Non-Commercial–ShareAlike 3.0 Creative Commons License, the full text of which can be consulted at http://creativecommons.org/licenses/by-nc-sa/3.0/. You are free to share, copy, distribute and transmit the work provided that the author is credited and reuse of the material is restricted to non-commercial purposes only and that if you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one. 

 

Copyright ® 2013 by Spanish Society for Microbiology (SEM)