International Microbiology, Vol 20, No 3 (2017)

Mechanisms of the evolutionary arms race between Vibrio cholerae and Vibriophage clinical isolates

Minmin Yen, Andrew Camilli


This review highlights recent findings on the evolutionary arms race between the causative agent of cholera Vibrio
cholerae and virulent bacteriophages (phages) ICP1, ICP2, and ICP3 isolated from cholera patient stool samples. We discuss
mechanisms of phage resistance such as a unique phage-inhibitory chromosomal island and mutations that affect phage receptor
expression. We also discuss the molecular characterization of ICP1 and its unique CRISPR-Cas system, which it uses to combat
the phage-inhibitory chromosomal island. The role of phages in the life cycle of V. cholerae has been increasingly recognized and
investigated in the past decade. This article will review hypotheses as to how the predator-prey relationship may have an impact
on infections within individuals and on the self-limiting nature of cholera epidemics. In addition, we put forth a strategy of using
phages as an intervention to reduce household transmission of cholera within a community.

Full Text: PDF

Sello de Calidad FECYT



5-year Impact Factor of International Microbiology is 2,10.

The journal is covered in several leading abstracting and indexing databases, including the following ones: AFSA Marine Biotechnology Abstracts; Biological Abstracts; Biotechnology Research Abstracts; BIOSIS Previews; CAB Abstracts; Chemical Abstracts; Current Contents–Agriculture, Biology & Environmental Sciences; EBSCO; Embase; Food Science and Technology Abstracts; Google Scholar; IEDCYT; IBECS; Latíndex; MedBioWorld; PubMed; SciELO-Spain; Science Citation Index Expanded; Scopus


Creative Commons License

This work, including photographs and other illustrations, unless the contrary is indicated, is subject to an Attributions–Non-Commercial–ShareAlike 3.0 Creative Commons License, the full text of which can be consulted at You are free to share, copy, distribute and transmit the work provided that the author is credited and reuse of the material is restricted to non-commercial purposes only and that if you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one. 


Copyright ® 2013 by Spanish Society for Microbiology (SEM)