Multidisciplinary approaches towards compartmentalization in development: Dorsoventral boundary formation of the Drosophila wing disc as a case study Authors Javier Buceta Department of Chemical Engineering, Lehigh University, Bethlehem, PA, USA Abstract Lineage restriction boundaries set stable barriers during tissue growth that compartmentalize the primordia and promote their patterning. This discovery was a major breakthrough in modern biology because of its powerful conceptual implications regarding the developmental plan in both vertebrates and invertebrates, the subject of this short review. As a leitmotif, we focus on our own recent contributions to the problem of dorsoventral boundary formation in the wing disc of Drosophila, paying special attention to recent multidisciplinary approaches that have shed light on the gene regulatory interactions and biomechanics underlying the compartmentalization process.Keywords: compartmentalization · developmental biology · systems biology · biomechanics · gene regulatory networks Downloads PDF Issue Vol. 9 No. 1 (2013) Section Celebration of the Centennial of the Catalan Society for Biology, 1912–2012 License This work is subject, unless the contrary is indicated in the text, the photographs or in other illustrations, to an Attribution —Non-Commercial— No Derivative Works 3.0 Creative Commons License, the full text of which can be consulted at http://creativecommons.org/licenses/by-nc-nd/3.0/. You are free to share, copy, distribute and transmit the work provided that the author is credited and reuse of the material is restricted to non-commercial purposes only and that no derivative works are created from the original material.
