Aminoacyl-tRNA synthetases: a complex system beyond protein synthesis

Authors

  • Teresa Bori-Sanz
  • Tanit Guitart
  • Lluís Ribas i de Pouplana

Abstract

Aminoacyl-tRNA synthetases (ARSs) are enzymes that translate the genetic code by adding amino acids to their cognate transfer RNAs (tRNA). Aminoacylated tRNAs can then be used by the ribosome to decode mRNA. The essential role of ARSs was established in the 1960s, during the golden era of molecular biology that led to the discovery of the genetic code. The canonical role of these enzymes is now described in all textbooks. Remarkably, however, interest in ARS function continues to grow as new and unexpected functions are discovered for these enzymes, for tRNA, and for RNA in general. This article describes current progress in the field of ARS research, summarizes current thinking about the evolution of ARSs, introduces the readers to the many facets of cellular biology in which ARSs play an important role, and discusses the biotechnological applications derived from these studies.

Published

2007-09-14

Issue

Section

Research reviews